Infectious Disease Compendium



Spleen gone. Usually not a subtle finding on history or CT; Howell-Jolie bodies can be a hint on the smear.

Epidemiologic Risks

Trauma (you do wear your seat belt?), sloppy surgeon, the following incomplete list can act as if they are asplenic: Alcoholism, amyloidosis, autoimmune hemolytic anemia, biliary cirrhosis, bone marrow transplantation, celiac disease, chronic active hepatitis, chronic graft vs. host reaction, chronic myelogenous leukemia, collagenous colitis, essential thrombocythemia, Graves' disease, hairy cell leukemia, Hashimoto's thyroiditis, hemangiosarcoma of the spleen, hemophilia, hematologic diseases, hereditary spherocytosis, Hodgkin's disease, idiopathic thrombocytopenic purpura, non-hodgkin's lymphoma, ovarian carcinoma, portal hypertension, rheumatoid arthritis, right sided heart failure, sarcoidosis, Sjögren's syndrome, splenic irradiation, systemic lupus erythematosus, thalassemia, ulcerative colitis, Whipple's disease.

It is not that they get more infections, but that they get worser infections (Purpura fulminans), especially with encapsulated organisms.


Streptococcus pneumoniae, Haemophilus influenzae, Salmonella, Capnocytophagia canimorsus, Malaria, Babesia, Meningococcus. B. holmseii can cause bacteremia and it peaks with Pertussis cases (PubMed).

Empiric Therapy

Vancomycin and (a third generation cephalosporins OR carbapenem OR penicillin/beta-lactamase inhibitors OR quinolone).


There is this neat thing out called the vaccine and it exists for both Streptococcus pneumoniae and Haemophilus influenzae. Perhaps it would be nice to give the vaccine BEFORE you remove that spleen.


I remain amazed at the number of splenectomy patients who have not been warned that they can get sicker than stink faster than a Republican can go to war. Tell your patient about the seriousness of fever and give them the damn vaccine. How often? My bias is the pneumococcal vaccine every five years and I suggest both the old carbohydrate AND the newer conjugated. This is a clinical trial free practice, but when you look at the pharmacokinetics of antibody after vaccine in the asplenic, it seems prudent.

ICD9 Codes (Soon to be supplanted by ICD10)

Asplenia 759.0.