Dosing

CrCl Formula

CrCl > 80: 100 po/iv q 12 h.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Deposits in bone and teeth, photosensitivity.

Important drug interactions

Acitretin, aluminum, calcium or magnesium containing products, bismuth subsalicylate, carbamazepine, cisatracurium, dicumarol, ethinyl estradiol, fosphenytoin, iron, isotretinoin, mestranol, methotrexate, norelgestromin, norethindrone, norgestrel, phenobarbital, phenytoin, rapacuronium, rifampin, rifapentine, warfarin.

Rants and Screeds

Pearls

Treatment of choice

Use for

Anthrax (post-exposure prophylaxis, gi,pulmonary and cutaneous), bacillary angiomatosis, Acinetobacter infections, acne, actinomycosis, amebiasis, Bartonella, bronchitis, Brucella, Calymmatobacterium granulomatis, Campylobacter fetus infections, chancroid, Chlamydia infections, cholera, Clostridium infections, colonic surgery prophylaxis, pneumonia-community-acquired, conjunctivitis, COPD exacerbation, donovanosis, Ehrlichia chaffeensis infections, Enterobacter infections, Epididymitis, Escherichia coli, Gonorrhea, granuloma inguinale, hysterectomy, Leptospira, Listeria monocytogenes, Lyme disease, Lymphogranuloma venereum, Malaria, malignant pleural effusions, Mediterranean Spotted Fever, Meliodosis, Mycobacterium infections, Mycoplasm pneumoniae infections, nongonococcal urethritis, onchocerciasis, Psittacosis, PID, periodontal disease, periodontitis, plague, pneumonia, postabortal infection prophylaxis, pre-menstrual syndrome, Proctitis, Q fever,Relapsing Fever, Rickettsia conorii, Rocky Mountain Spotted Fever, rosacea, sclerotherapy, scrub typhus Rickettsia, sexual assault, Shigella, Sweets syndrome, Syphilis, Toxoplasma, travelers' diarrhe, tularemia, typhus, urethritis, UTI, Vibrio cholerae, Vibrio vulnificus, Vincent's infection, yaws, Yersinia pestis.

Don't use for

Class

Tetracycline.